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KMID : 0986520110110040269
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Korean Journal of Endoscrine Surgery
2011 Volume.11 No. 4 p.269 ~ p.275
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Clinical Analysis of Pheochromocytoma and Abdominal Paragangliomas
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Kin Sang-Hoon
Jung Seung-Pil
Lee Jeong-Hee
Kim Ji-Young
Choi Min-Young
Lee Se-Kyung
Choe Jun-Ho
Lee Jeong-Eon
Kim Jee-Soo
Nam Seok-Jin
Yang Jung-Hyun
Kim Jeong-Han
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Abstract
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Purpose: We compared clinical characteristics between pheochromocytoma and abdominal paragangliomas and identified predictive factors of malignancy.
Methods: Between November, 1995 and January, 2011, we retrospectively reviewed the medical records of 145 patients with pheochromocytoma and abdominal paraganglioma at Samsung Medical Center. We compared two tumors (pheochromocytoma vs abdominal paraganglioma) about a potential of hypersecretion of cathecholamines and identified predictive factors of malignancy by analysis of clinical characteristics, biochemical markers, tumor features. Their postoperative results were also evaluated.
Results: This study included 103 (71%) pheochromocytomas and 42 (29%) abdominal paragangliomas. Eighty-six percent were benign and 14% were malignant. Patients with paraganglioma were more predominantly men and exhibited a higher malignancy rate (P＜0.01) than pheochromocytoma patients. Most (95%) pheochromocytoma was hyperfunctional, but abdominal paraganglioma were hyperfunctional in 74%. There were no significant differences in biochemical markers between the pheochromocytoma and paraganglioma groupd. When compared with benign tumor, malignant tumors were significantly related with higher mean PASS (P＜0.01) and higher 24-hour urinary VMA (P=0.02), but not with larger tumor size.
Conclusion: It is not easy to distinguish malignant from benign tumors by clinical characteristics and pathologic features in the management of pheochromocytoma and paraganglioma. We should keep in mind that abdominal paraganglioma can be also hyperfunctional in many pheochromocytoma patients and has a higher risk of malignancy.
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KEYWORD
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Adrenal gland, Malignant pheochromocytoma, Paraganglioma
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